Periapical tissue reaction to calcium phosphate root canal sealer in porcine model

Periapical tissue reaction to calcium phosphate root canal sealer in porcine model

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Background: Calcium phosphate cements (CPC) are a group of aluminum lotion biomaterials possessing wide scope of use in various branches of medical science.These materials have been proposed to be highly biocompatible and osteoconductive.This study is based on a newly developed CPC formulation (Chitra-CPC) and is aimed at the evaluation of its biocompatibility through an Endodontic Usage Test in a porcine study model.Objective: To evaluate the periapical tissue reaction to Chitra-CPC when used as a root canal sealer/filler material in comparison with a resin sealer, AH Plus (Dentsply).Materials and Methods: The procedure was done on porcine animal model following the ISO 7405 criteria.

The material was implanted intentionally into the kenya tree coral for sale periapical area of 36 teeth through a root canal procedure carried out in six animals which were divided equally among 1-month and 3-month time periods.Results were based on the histological evaluation of the autopsied specimens after the prescribed time periods.Results: Mild to moderate periapical tissue reaction was found in Chitra-CPC samples belonging to the 1-month time period, whereas majority of the 3-month CPC samples showed an absence of inflammation.Samples of AH Plus in 1-month period showed severe to moderate inflammation, whereas 3-month AH Plus samples had a mild to moderate inflammation.Conclusions: Chitra-CPC is a biocompatible material.